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Bryan Johnson and HBOT: What His Blueprint Protocol Includes

Bryan Johnson spent roughly $2 million per year on anti-aging interventions and documented everything publicly. His Blueprint protocol became one of the most widely discussed self-experimentation projects in biohacking. HBOT is part of it.

This page covers what he’s actually said about HBOT, what the research he cites actually found, and what you can realistically do with that information.

Who Bryan Johnson Is

Johnson founded Braintree, a payment processing company, and sold it to PayPal for $800 million in 2013. He then founded Neuralink competitor OS Fund and later Kernel, a brain-computer interface company. He’s a serious technologist, not a fitness influencer.

In 2021, he publicly launched Blueprint, a project to reverse his biological age using a rigorously tracked protocol of diet, sleep, exercise, supplements, and medical procedures. He publishes his protocol, labs, and outcomes at blueprint.bryanjohnson.co.

His visibility brought many investigational health interventions to mainstream attention. HBOT is one of them.

What His Protocol Actually Includes

Johnson has publicly disclosed using HBOT as part of Blueprint. He uses clinical-grade sessions at 2.0 ATA, 60 minutes per session, at a clinical facility. He does not use a home soft chamber for this purpose.

The study he cites most often is Hachmo et al. (2020) from the Efrati lab at Tel Aviv University. That study found telomere lengthening of 20 to 38% and senescent cell reductions of 11 to 37% in 35 healthy adults over 64 after 60 HBOT sessions at 2.0 ATA. See our full breakdown at HBOT and telomeres.

Johnson’s protocol changes. He publicly updates Blueprint when his biomarkers or new research warrant changes. Don’t treat any third-party summary — including this page — as current. Check blueprint.bryanjohnson.co directly.

The Gap Between His Protocol and What Most People Can Do

Johnson’s full intervention stack runs over $2 million annually. Even isolating the HBOT component reveals a significant gap.

Clinical HBOT at $250 to $450 per session for 60 sessions costs $15,000 to $27,000. That’s without counting the physician oversight, monitoring, and other protocol elements he uses. Most people can’t run this protocol.

Home soft chambers at $4,000 to $17,000 are the budget alternative people explore after discovering his protocol. But here’s the problem: he isn’t using a home chamber. The telomere research was done at 2.0 ATA with 100% oxygen. Home chambers at 1.3 ATA with ambient air produce roughly 1.5 to 2 times normal plasma oxygen levels. Clinical-grade HBOT at 2.0 ATA with 100% O2 produces roughly 20 times normal plasma oxygen. These are not the same thing.

A home chamber may offer some wellness benefit. It won’t replicate what the Tel Aviv study measured. See Clinical HBOT vs. Home Chamber for the full comparison.

If you’re exploring home chambers, see our guide on best home hyperbaric chambers for what to look for before purchasing.

What the Evidence Actually Supports

The Hachmo (2020) study is legitimate research from a credible group. It showed measurable changes in cellular aging markers. That’s interesting and worth tracking.

It did not prove HBOT extends human lifespan, reverses clinical disease, or produces the same results in all people. Johnson is a self-experimenter. His individual results are data points, not a clinical trial. He’s also an exceptionally healthy person with comprehensive medical monitoring, which creates conditions unlikely to generalize.

The honest summary: the mechanism and the preliminary evidence support further research into HBOT for aging. Johnson’s public documentation increased awareness of that research. But calling this an established anti-aging protocol based on one 35-person study and one person’s experiment is a stretch.

Anti-aging is not an FDA-approved HBOT indication. No insurance covers HBOT for this purpose. It’s investigational.

What You Can Realistically Do

If you want to explore HBOT in the context of the anti-aging research:

Find a clinical HBOT facility near you through the UHMS directory at uhms.org. Ask whether they offer protocols for wellness or investigational uses. Some facilities do.

Expect to pay out-of-pocket. $250 to $450 per session. Budget for at least 20 sessions if you want to evaluate any effect.

If you can’t afford clinical sessions and want mild-pressure home use, a home soft chamber is an option — but understand you’re not replicating the protocol the research used.

Track your own results. Johnson’s value isn’t that he proved HBOT works. It’s that he documented everything systematically. If you pursue this, do the same.

FAQ

Does Bryan Johnson endorse any specific HBOT brands? Not that he’s publicly disclosed as of early 2026. He uses a clinical facility, not a branded home product. Check his website for any current partnerships.

Is Johnson’s biological age actually younger than his chronological age? He publishes biomarker data showing improvements in various aging metrics. Whether these translate to actual biological age reduction in a validated clinical sense is debated. His tracking is rigorous by self-experimentation standards but isn’t a clinical study.

Are there other biohackers doing HBOT? Several high-profile figures in the longevity and biohacking space have explored HBOT. Dave Asprey has discussed it. Peter Attia has addressed it in his podcast. The consensus is that it’s interesting for aging applications but evidence is preliminary.

Should I try HBOT because Bryan Johnson does it? That’s a medical decision, not a celebrity-following decision. He’s one self-experimenter with access to extraordinary resources and monitoring. His protocol isn’t medical advice, and neither is this page. Talk to a physician.

Medical Disclaimer: The content on this page is for informational purposes only. It is not medical advice and does not create a doctor-patient relationship. HBOT for anti-aging is investigational and not FDA-approved. Consult a licensed physician before starting any hyperbaric therapy program.